Re: Benedict Cumberbatch /John Harrison [SPOILERS]
Without knowing how the film would have turned out I don't think we can say that it wouldn't have suffered from comparisons.
On that one particularly aspect I think it's safe to say their wouldn't have been major comparisons. It wouldn't have been Khan, and thusly their would be no major comparisons between Khan and Khan. Especially since they really are very different takes on the character anyway.
"Paradise protests too much." SFDebris