I remember that too.
To address the OP, I suppose it depends whether the nacelles generate power or simply use power from elsewhere.
I've also seem, as others have hinted, that the use of four nacelles may be where they are intended to be used in alternating pairs. The DS9 TM, for example, suggested a four nacelle version of the Defiant
pathfinder was used as a courier, using paired cores and nacelles.
For all we know, the Constellation
class and her ilk may have two warp cores and do the same. Why not use pairs instead of two larger engines, unless there's some advantage to it?