I agree that on what the next series is set isn't as important as the characters or getting good actors to play them, good writers to give them plenty to face and resolve. The setting does however influence what kind of characters we'd get and the stories they can tell.
Personally if they went for a starship next time I'd want it to have some age to it, so it wasn't a super-ship that could do everything and come out without a scratch.
Commander Austin Harris, First Officer, Deep Space Nine (by FltCpt. Bossco)
8.01 - Darkest Before Dawn
(Chapter 8 added, 12/09/2015)