TOS: Kirk - Never liked him
TNG: Wesley - I hate child geniuses
DS9: Worf - Got kinda sick of him and his honour
VOY: Seven - Overused to the point of being dull and uninteresting
ENT: Archer - How did he become Captain?
NuTrek: NuUhura - She is just awful
If I had to choose one, since she's here to stay for at least one more film to grate on every single nerve I have, it's got to be NuUhura.