I think most of us agree a new series would be a good thing (if done properly), but what setting would you like to see it on?
I don't mean Prime/Nu universe, but on what actual structure would you want the action to take place?
A single starship - The classic format.
A fleet - Multiple ships/characters.
A station - One that doesn't have a wormhole nextdoor.
A colony - A new home in the unknown.