-No TOS inspired story
-No TOS inspired antagonist
-No TOS inspired secondary characters, like M'Benga or so.
By the very premise of the reboot, the films have set themselves up for exactly these elements. Everything is there, waiting to be "rediscovered." A TV series could explore "new" plotlines, but the next Trek film will almost certainly capitalize on the aforementioned aspect, just as STiD did.
Look for the Doomsday Machine or V'Ger, with a Klingon subplot thrown in (maybe sprinkled with some no-nonsense Organians).