The post-nuclear horror story would be interesting, as it would be Trek but not as we know it, dealing with a very dark time in human history. You have a lot of empty space to fill in but also a ton of future canon to keep track of as well.
I always like "what if's". I would personally love to see B'Etor serving on the E-D, I can imagine some good scenes between her and Riker.
Commander Austin Harris, First Officer, Deep Space Nine (by FltCpt. Bossco)
8.01 - Darkest Before Dawn
(Chapter 8 added, 12/09/2015)