Avatar 2: big evil mining company returns to pandora and bombs the shit out of the planet from orbit getting rid of the pesky natives. Wholesale mining of the planet begins
Avatar 3: mining continues
Avatar 4: mining continues until no more unobtainium left, move onto the next planet
Clearly I was under the mistaken impression that we were talking about what James Cameron would possibly do with the sequels, not what would happen if the situation were real and involved spaceships and modern armies vs. Indian Smurfs.