The funny part is that Columbus was going on a mission to a non-existent location based on phony science, with absolutely no convincing reason for making his journey. And it still lead to world-changing results. But let's dismiss things that actually have arguments to support them.
"No convincing reason" isn't right. Europe needed a sea route to Asia to facilitate trade:
Also his intended destination was real and the science for a round Earth was not phony.