If we ever get a new TV series set in the TOS era, it will most probably be with new actors, since I doubt they can afford to pay the fees demanded by Pine etc.
This is why I think maybe a CGI animated series would be the go. Even if some the cast don't
turn up to the table, it would be much easier to hide the change of voice actor than it would be to recast a similar 'actor type' in live-action. I'd like to hope the nuTrek cast would be willing to do voice work for an animated series though. One thing I felt actually worked
about the recent Xbox/PS3/PC game was that the voice acting was very strong from all concerned, and it made me realize just how good this cast could be in an animated Star Trek series.