Aerosmith had a big run in the late 70s, and made an amazing comeback in the 90s. I was floored at the number of great songs on the Pump album that were commercially viable. There wasn't a dud on the thing, and every song could have been released as a single. They became a virtual hit machine.
Let's not forget Eric Clapton. That man (one of my personal heroes) has done everything you can do with a guitar in your hands and has managed to continually create great music for 50 years. And he's still going strong.