It's interesting that everyone sees the middle segment as a Smurfs riff when it really drew more on Strawberry Shortcake
, a show that was based on a toy line for young girls. But then, that was apparently a series of annual specials rather than a full series, so maybe that's why it's less well remembered. Or maybe it's just that a lot of male viewers never saw the show. I was aware of the franchise from the commercials, but I can't say I ever watched it.
I suppose there were a few Smurf-based elements to it, like everyone being the same color. The Professor did have a Gargamel-like quality, though I think he was based on the Strawberry Shortcake
villain, who lived in a large hilltop residence made of metal cookware, according to Wikipedia; the rendering here of the Planet Express building seemed to fit that description somewhat.