The design of the NX-01 never bothered me all that much. I was hoping to see a Dadelous class ship when the show first started, but, oh well...
I was always very 'meh' towards the design. I did see the upsidedown Akira in there and missed the lack of a secondary hull, but she did have a few nice elements, whilst all the sets inside were good and practical--just what a ship of that era would need.
Though I would have loved for the series to be Daedalus-based, especially seeing the artwork that's out there now of an updated look for the Class. If I were the one making a pre-TOS series, that is the ship I would have based it on.