In may own take on the Enterprise
deck plans, turboshafts run through the various hull pressure compartments and there are emergency doors which seal off the tubes if that compartment is compromised. This does mean that the length of tube in the compromised compartment is not accessible. But, that's okay, because I've made sure that every section of the ship is accessible by means of stairs, ladders, and regular hallways.
BTW, in my arrangement, the tri-ladders are only those ladderways which interconnect hull pressure compartments. Since they are in their own tubes, they are easily sealed off in the event of a breach.