I use Strata 3D (www.strata.com
It's the program used to make Myst years ago.
Modeling is pretty easy (well, as easy as it can be to do anything in 3D) and the interface is pretty simple as well (as easy as it can be for a 3d program).
Animation is a pain, but it's always a pain in 3D.
But overall, Strata is a great, easy to learn program. I've tried Lightwave, Maya, Carrara...nothing is easier to learn than this.