I'm still very near the beginning so admittedly not enough of a sample to tell if this handholding continues.
But I got several hours into Uncharted 2 and it was all either a tutorial section or there were NPCs telling you 'Go here! Now go here! Now shoot that guy!' I'm hoping Last Of Us doesn't turn into that, and there are more parts of the game where you're just on your own.
Well, there are definitely parts where you just have to follow other characters around. They lead you through the story. But there's plenty of running around by yourself.