1) Original stories. No rehash.
2) I may be in the minority here but I'd like to see more of the federation. More ships. More of the different designs. More of the inner workings of the federation (assuming it's well done and not another the-federation-is-corrupt storyline).
3) And most importantly: I'd like to have the technical and canon advisers have some real authority. When a writer/director/producer suggests transwarp beaming or says that 78 decks seems more dramatic, the adviser gets to smack 'em upside the head and make them go sit in the corner.
Also, 4) throw a bunch of money at Rick Sternbach and get him to do a big batch of ship designs. Man, do I miss his stuff.