Frankenstein's abandoning his creature can be read as directly paralleling God abandoning humanity. Of course it is possible to somehow miss this, as it is pretty much like saying God is evil for leaving us without guidance yet condemning us to hell if we subsequently do wrong.
The framing story of Walton the explorer is more susceptible to a "things man is not meant to know interpretation." But is it a ploy for deniability or a mask for the author? Given the close parallels between Frankenstein and God, even this can be read as denying the value in theology,
not science. Especially as this was written when scientist was hardly a word. Frankenstein's vain pursuits in alchemy=inquiry into God's plan of creation?