An interesting villain who faced off against the 30th century Guardians of the galaxy was Wolverines daughter Rancor. Becuase their blood line is practically immortal, the family credo was "If you can't kill someone and take their shit, wait for them to die of old age, and then take their shit."
Nebula is Blue, with blue hair. That's hot. My money is on Nebula, unless they invent someone new?
Just because Karen is a hot skinny red head, it doesn't mean that she's going to play someone hot, skinny and female.
What if Karen is playing Thanos?