Yes, but all the focus would be on River and Jack with Vastra and co. as background players.
Well, for the bulk of the story, split everyone up. Have River with Vastra and Jenny, and Jack with Strax. Mainly so you can have this scene:
For some reason, a woman strips her clothes off in front of Jack and Strax.
Jack: "Oh boy!"
Strax: "Ah, so this one is