Re: Oh come on Spock, it sucks! Big Deal. (SPOILERS)
In fact the only times he ever really cares about it is when the bad guys are doing it to either mold the pre-warp civilization to their liking or to get rich after killing a shit load of natives to suck up to another group.
Or if another Starfleet captain has violated the Prime Directive. Then it's wrong. Consistent in both timelines (Captain Tracey in The Omega Glory, Captain April in the comics).
"Internet message boards aren't as funny today as they were ten years ago. I've stopped reading new posts." -The Simpsons 20th anniversary special.