Re-arrange existing ships and crews (not just main ships and characters if you want) and build your ultimate ship and crew of choice.
Ship: USS Prometheus
First Officer: Riker
Security Chief/Tactical: Tuvok
Chief Operations/Science Officer: Data
Chief Engineer: O'brian
Medical Chief: The Doctor (Bashir was close)
Chef: Guinan (Neelix may be more exotic and Quark gets hard to find items but Guinan has all the stories)
Extra info: When the USS Prometheus separates it'll be Picard with Tuvok, Riker with Paris, and Data with O'brian in the saucer section.