The question is Andre vs. Worf, not Andre vs. Michael Dorn.
The question was actually Andre the Giant
vs Worf, not André Roussimoff.
Just this. Andre the Giant (unlike André René Roussimoff) did not have back problems and other health issues, he was a massively powerful, near super being. He would have thrown Worf around like a rag doll.
And if Worf were foolish enough to pick up a bat'leth, Andre would have beat Worf senseless with the ultimate weapon.
A folding metal chair.