I was very pleased with that 2:30 trailer for the show.
The fact that, from that promo, it sounds like an X-Files, Millennium, Fringe, W13 or Alphas is proof enough that this concept works. It's just got an already established universe of material from which to draw. Things will be new to most but the easter eggs for the faithful will be fun to find.
I'm rooting for Moon Knight, Mockingbird, Justice, Machine Man, Jessica Jones, Misty Knight to name a few that should the show go a few seasons could be seen in some story manner. A few Halloween themed episodes with say Jack Russell the Werwolf by Night, N'Kantu the Living Mummy or Manphibian anyone? Do I dare think Man-Thing?