Made a little bit of progress last night... after I got my Workstation back up. It turned out that the Star Trek game installed a DirectX update, which I think contained a Windows 7 platform update, which didn't like the latest nVidia drivers. After I removed the DirectX update, and rolled back to my old drivers, it was all working. The new cards are coming in this week anyway, though.
More soon. It's really starting to come together.