Captain Kathryn it's at the end of the sixth season and is a truly terrible episode. And I love the Ferengi with all my heart. It would have to be in my top 5 most disliked eps (of which I can only think of 3, that's how stupidly generous I am with Star Trek).
Still, don't skip it.
I don't skip episodes anyway, but especially not Quark with woman boobage.