SF@Seattle (in Week 2) is an NBC Sunday night game, but Seattle@SF (in Week 14) is just a Sunday afternoon game. Granted, the latter is in the "flex" portion of the schedule, so there's always an outside chance that it'll get moved to Sunday night if the intrigue is high enough.
As much as people in general like San Francisco and Seattle (and fans of other teams may disagree), I don't think it's fair to award the SNF game twice in one season to the same match-up. There are 30 other teams that play home-and-away games, in fact every single team plays three of them each year. What makes SF vs SEA the most intriguing of them all?