It seems that the general consensus is that Q is so far above the others that if he doesn't want them to exist, there's not much they can do about it. This is obvious in the case of Romulans, changelings, and androids, but Douwds, Organians, Trelane, Metrons, etc., are depicted as being very advanced. (Trelane had his machine but was still very advanced compared to humanoids.)
It would be interesting to note whether dispatching of a Douwd or Organian would be 'harder' for Q (even infinitesimally so), or if eliminating a very powerful being would be as simple as destroying a Tribble or a Kelvan.
Also, I wonder if the combined might of these beings could injure Q (however slightly). This is assuming that Q is somehow 'taken by surprise,' or whatever, and he just doesn't vanish them away immediately.