"Sometimes they treat you like you have a brain the size of a pea!"
Then I took advantage of the opening. "Well in your case, Wilma..." and didn't finish.
Even the manager laughed, and I didn't get a reprimand. I did apologize as it hurt her feelings.
In my office (a bunch of engineers), that wouldn't hurt anyone's feelings, since it would be taken (and intended) as good-natured ribbing. Happens quite a bit in our meetings, actually!