That's one of the reasons I liked TIM as the antagonist in the second game. He represented the human element that doesn't want to be looked at as equals to all the other races in the galaxy. He wants humanity to be the 'dominate power' over everyone else and he was willing to do whatever it took to ensure that goal.
It'd be interesting to do a super pro-human, anti-alien Shepard sometime, having Ashley kill Wrex on Virmire, and then ensure only Miranda, Jacob, Jack, Kasumi, and Zaeed survive the suicide mission. Unfortunately, Liara is completely unkillable in ME3... *grumble*