My guess is we should say goodbye to Hershel, Beth and Judith.
Carol is safe because they just took someone from Daryl.
Glenn and Maggie will have their happiness shattered when Maggie loses the last of her family (and it set up things for Maggie's next step in the comics)
Rick and Carl as central to the story, and unless either wants to leave the show, I see them as safe too.
Michonne and Andrea will survive so Michonne can continue to be pissed at Andrea's poor judgement.
Tyreese will survive, maybe not his sister.. and they can hook him up with Michonne.