Probably the all-out worst location for TOS is Uhura's chair. Communication shifts are monotonously long and beamdown privileges are so infrequent that bedsores are inevitable. Highlights of her day are being rendered unconscious, practically electocuted, zapped into cube-form or getting mentally freaked out by Bizzaro-Spock.....usually without leaving the chair.
Best location? Spock's. He's got the minature adult film viewer at his console which only Chekov gets to share.