Well, obviously the show would not have that name, but how about a detective/investigation show set in the Trek Universe?
As the sole focus of a Trek series? No, I really don't think so, however what was maddening about modern Trek was they always had the CSI option built in and hardly ever used it (or any of their other options).
By design, Star Trek was imbued with the unque feature that it could be anything it wanted to be from one week to the next. Whether on a ship or a space station each series had a variety of jobs and talents represented on a regular basis and thereby had the characters on-hand to carry any plot or story. Sadly, ownership/management (Paramount and Rick Berman) never were able to see the full potential of what they at their fingertips from the start.