The lengthy, emotional exchange between Dante and Randal in the jail cell towards the end of Clerks 2 always gets me. Kevin was always impressed and touched at how Jeff Anderson knocked that dialogue out of the ballpark and did it with such believable emotion and body language. The jail sequence shows how much Dante and Randal really love one another as friends even if one wants to strangle and kill the other from time to time.
That scene is hands down my favorite scene from any of Kevin's movies. The directing, writing and acting were, in my opinion, perfect, and could not be improved upon.