And of course other movie series have recast their leads, often more than once. James Bond is the classic example, and there are the '80s and '90s Batman movies, but it happened a lot in the early days too -- the Universal Dracula and Frankenstein films, Tarzan films, Perry Mason (who appeared in a movie series starting in the '30s), etc. Not to mention all the recast leading/supporting ladies like Saavik, Rachel Dawes, April O'Neill, Elizabeth from Back to the Future
, Evie from The Mummy
Although it doesn't always prove successful. There was a 1968 film called Inspector Clouseau
, the third film with that character, which was made without the involvement of Peter Sellers or Blake Edwards, starring Alan Arkin in the title role. It basically killed the series until Edwards and Sellers resurrected it in 1975.