Of course, the whole "set a course for home" thing was basically self-deluding. The 75-year estimate to get home was a best-speed sort of thing, and given how many times they stopped somewhere or got sidetracked, it realistically would've taken centuries if they hadn't found all those shortcuts. What they should've done was found some advanced, benevolent civilization they could ally with and settle in, then use their technological resources to develop a means of establishing regular communication with the Federation.
Also, I have a hard time forgiving Janeway for never bothering to look for any of the other refugees abducted by the Caretaker. They should've tracked them all down and banded together, traveling in a caravan for mutual support and protection. Maybe they could've found the Equinox
earlier and spared them from five years of hell.