A sci-fi show aimed at people who dislike sci-fi is just dumb. It works for popcorn movies to be sure but I doubt the general audience will stick with it for 7 seasons or whatever.
You mean like Lost? Or maybe Walking Dead? Or how about Game of Thrones? What we've seen is the exact opposite. Shows that limit themselves to sci-fi fans can't get the audience to last one season, while shows aiming for a broader appeal are hits for their network.