There's a lot of great lines in Trek. Two lines that I remember now, and that were meant to be only somewhat funny at best (but which crack me up every time):
McCoy, in TMP, after hearing that V'ger wants to join with its creator: (muttering under his breath):
"Touch God...? V'Ger's liable to be in for one hell of a disappointment
because of its sheer cynicism, and
"if there's nothing wrong with me, there must be something wrong with the universe!
(dr. Crusher, remember me) -- I only wish I
could muster that kind of self-esteem