The 1980s version of the series Astroboy (the only Astroboy series I was exposed to) explored this rather heavy handed theme in nearly every episode yet made it very entertaining and approachable to kids as well.
Actually, that was a central theme of Tezuka's original comic (manga) in the 50s, years before it was first adapted to animation in the early 60s.
If you're genuinely curious, Dark Horse Comics reprinted select stories (in English) in pocket sized omnibus collections several years ago. It might be a tad tricky to get them now as I assume they are out of print. I know DH released at least 20 something volumes (as those are the one I have), but the number may have been far more.