It's been interesting to see Worf go from a young junior officer to an experienced senior officer over the years. The idea of a Klingon commanding a Federation starship would have been unthinkable during TOS.
As far as the evolution of the TNG crew...I'm really just of the opinion that the Enterprise
-E will be around long enough to eventually have a totally different senior staff than the one she started off with. I think that was true for the original Enterprise
in which perhaps none of April's original senior staff was around by the time Kirk took over some 20 years later.