Audiences can understand TWoK perfectly without having seen Space Seed (I saw the movie before I'd seen a single episode of TOS!), but it really does enhance the experience having seen Kirk and Khan interact face to face.
BillJ wrote:

Yet you wonder how people can enjoy Star Trek 2009. Your statement above is exactly how I feel about that movie.
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Both are probably solid dumb popcorn movies that appeal to a wider audience much more than they do fans, who get bothered by the huge holes.