One disadvantage of pilorless drones, at least from Trek's "more enlightened" vantage point is that when you can wage war without putting your people in harms way you're less likely to take a step back. Consider the current US use of drones world wide. There's been hundreds of sorties flown and many civilian casualties but it's not considered newsworthy because none of the people killed are Americans. As long as the deaths of foreign civilians stays out of the headlines and the American publics consciousness the drone strikes will continue. It's sort of a one sided version of A Taste of Armageddon. The Americans have no reason to stop because their people are safe and secure. The targeted countries have no way of retaliating directly at the American military. The best they could do is launch "terrorist" attacks, probably at civilian targets. The US military could then use those to claim that they have to continue or even expand their use of drones.
As long as one side doesn't face any consequences for attacking another then the attacks will continue, in the real world as well as the fictional one.