I think that a measure of success may be in re-purposing this show from the point of view of a handful of nerdy girls. There's a certain mystique in nerd girls/geek girls that might have some potential for a series to either compete with or add to the TBBT universe.
Who knows? Maybe there will be a Dr. Amy Farrah Fowler
spinoff. But the series shouldn't last too much longer... the ideas are starting to tread water. The Howard in Space storyline was kind of exhausting.
Let's 2.5 Men this:
The plot revolved around [Alan] being spoiled by [Charlie/Ashton] regarding a plot point in a Harry Potter book (not nerdy in the slightest). In response, he decides to move out, into [current whats-her-face]'s apartment. This opens up the door for [current slut] to move in to [Charlie/Ashton's house]. Ultimately, the issue is resolved by [what's-her-face] and [Charlie/Ashton]'s mutual desire to not live with their S.O., and status quo being returned. A subplot involves [Jake] being forced to spend the weekend with [Charlie's mother], who smothers him much to his discontent. [I dunno, some minor characters, maybe Judith and Herb] attend a retreat for [Judith/Herb's] company and attempt to have Cirque Du Soleil sex.
I thought I had a general grasp of the characters of 2.5 Men but I admit I don't know Judith or Herb. Anyway, nice plot reformatting.