The scene in the Prophet recreated Saratoga corridor from Emissary
TACTICAL: But this is your existence.
SISKO: But it's difficult to be here, more difficult than any other memory.
SISKO: Because, because this was the day that I lost Jennifer. I don't want to be here.
JENNIFER: Then why do you exist here?
SISKO: I don't understand.
JENNIFER: You exist here.
As someone who has lost quite a few friends and relatives along the way, this is the scene that resonates the most for me from all of Trek.