Greg Cox wrote:

"The slightly shady crew of a ramshackle spaceship try to keep flying, while staying one step ahead of the law . . . ."
Trust me, just about any plot can be boiled down to three paragraphs (or less) of back cover copy! 
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I suppose. The issue, IMO, isn't so much whether such a synopsis is possible. The issue is whether a show can be easily boiled down to one idea by a common viewer in a way that he can tell outsiders what the show is.
Buffy &
The Avengers both had an advantage in that they were part of familiar genres. You don't have to say much before people start understanding what you're talking about because it evokes ideas of things they've seen before.
BTW, Mr. Cox, you can summarize
Firefly. But can you distill
Dollhouse?