Re: Poor Uncle Owen and Aunt Beru... Oh Well!
If you follow the EU then there were dozens (hundreds?) of Jedi who survived the initial implementation of Order 66, and Vader spent most of the time between the two trilogies hunting down the last of them. I'm not sure but I swear I remember reading somewhere that by the time of ANH he was closing in on the last few Jedi.
Over the course of many encounters and many years, I have successfully developed a standard operating procedure for dealing with big, nasty monsters. Run away. Me and Monty Python.
Harry Dresden - Blood Rites (The Dresden Files #6)