if you have a "command" module and some slaved "drones", and the command module was destroyed...that would suck.
But having a command module does away with the M-5 problem: you have a local man in the loop, even though you don't risk any lives.
Or you could just have a large Galactica or Andromeda type carrier and multiple smaller drones.
is fun especially for its ditching of the carrier concept and giving the job of "carrying" to the drones - rather sensibly so, as big engines have their rightful place on the drones themselves. A carrier-plus-drones deal would be fun in its own terms, but probably not the same thing as the Prometheus