The matter/antimatter bomb beamed down in TOS: Obsession says yes.
That was short and - painless?
Funny, I was asking myself whether you could use anti-tritium and anti-deuterium in a nuclear fusion reactor to put the onboard antimatter to some productive use before it vanishes in controlled matter-antimatter annihilation.
The problem are the anti-neutrons you'd get in such an antimatter nuclear fusion reactor. A magnetic containment will only work with charged particles and neutrons aren't among these. Thus the anti-neutrons would pass through the containment and that would the end of an antimatter nuclear fusion reactor.