A is for A Deck....on Earth and later Federation starships that almost always means the main bridge.
B is for Beta Quadrant. Home of gaseous anomalies and an interstellar empire or two.
C is for Chapel. Nurse Chapel. Always a bridesmaid, never a bride.
D is for the Daystrom Institute.
E is for Excelsior.
F is for the Ferengi Tower of Commerce, the tallest building on Ferenginar and possibly the entire Ferengi Alliance.
G is for Gorn. Morn should have been a Gorn. Would have made Quark's a more interesting place. He could've ate the occassionally unruly customer.
H is for Hermes, USS.
I is for Imzadi. What Troi calls Riker.
J is for Jim.
K is for Kirok. He. Is. KIROK!
L is for Leonard Nimoy.
M is for Masks, a tour de force for Brent Spiner.
N is for Nerds. Nerds like Star Trek.
O is for Ovipositors. Xindi Insectoids laid their eggs with them.
P is for Power Coupling. Evidently the most vulnerable spot on the Enterprise-D. Especially the starboard one. Might I suggest increasing the shielding and armoring?
Q is for Quite lovely. All the women on Kirk's Enterprise were quite lovely.
R is for Romulus. R.I.P. 2387.
S is for Soran. A crazy old man always searching for trilithiUUUMMM.
T is for TrilithiUMMMMMMMMMMMMMMMM.
U is for Universal Armageddon.
V is for V'Ger's colossal size.
W is for William Shatner's ego's colossal size.
X is for the Xindi-reptilians' colossal shoulderpads.