I'd love to see a series that starts with the first generation born on a Generational ship as adults, the original crew still there but older etc.. trying to hold together the purpose of the mission. Let's say in 12 years VOY did decide to start breeding for replacement, You're going to have to indoctrinate the next generation into returning to earth being their heart's desire when they have minimal connection to it. Add a few more crew from the DQ and at some point you may have a rebellion wanting to settle somewhere.
I think that would be an awesome premise! The old folks trying to teach everyone how awesome Earth and the AQ is so they keep on heading home, meanwhile the young ones just want to find a place to settle down so they don't have to keep patching up the falling apart ship.